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Istradefylline 40 mg/day amplified peak stages and AUC of CYP3A4 substrates in medical trials. This result was not observed with istradefylline 20 mg/working day. Look at dose reduction of delicate CYP3A4 substrates.No specific dose adjustment recommended when tofacitinib coadministered with powerful CYP2C19 inhibitors; reduce tofacitinib dose if c
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